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verapamil gel caused my ED, can it be reversed?Hi,
Im 25, I've had great erections throughout my life, until I tried a generic compound verapamil hydrochloride 15% gel, because I thought it could help slight curvature I have. Duration of application was about a month and a week, once in the morning and once at night. I put it up and down the shaft of my penis, front, back, and sides... so it was in contact with my testicles. First few weeks I applied it morning and night, i would get an erection easily during application, and hard ones like I had always experienced. It would be difficult to lay down and for the erection to go away after gel application at night. The next weeks I saw a big change and I think im in trouble. During application I became not as hard, too rubbery/bendy/elastic.. it doesnt fill as well initially as before and its very difficult to maintain, taking longer to excite initially, filling/emptying FAST, with manual help, then none, with manual help, with none.. difficult to maintain. This is horrible. As soon as I applied the gel at night, my penis would shrivel up fast, almost becoming numb and I no longer get night wood. Trying to fall asleep because of hard wood is no longer an issue. Been getting some in the morning but not as strong. Only had one wet dream and it was like a wet noodle.. Shooting and spasming doesnt feel quite like before the gel, uptake velocity ISNT the same.. Never a problem before the gel and I am worried the gel did something to my smooth muscle tissue or nerves or other cells.. because I would get them all the time, at night, the morning, in the shower just through normal hormones but not anymore without physical help. And it doesnt stay engorged like before.. Anyone know whats going on here?? Does this sound like calcium channel ion reduction? ..Can this be corrected? I stopped the gel after I noticed the numbing, these signs ensued.. its been 6 months now and the signs continue. Below is a list of chemicals in the gel: Verapamil Hydrochloride USP (Medisca); [Krisgel 100 (TM); Pluronic F127 20%; Squalane NF (Liquid); Ethoxy Diglycol Reagent; Edetate Disodium; Butylated Hydroxytoluene (BHT) in Ethoxydiglycol; Water Distilled; Ecithin/Isopropyl Palmitate;] Water Distilled; Krisgel 100 (TM); Citric Acid. I have a few NDC's too. Some verapamil websites: http://www.mentalhealth.com/drug/p30-i03.html http://en.wikipedia.org/wiki/Verapamil "Verapamil is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). The mechanism of the antianginal and antiarrhythmic effects of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium through the slow channel (calcium ion antagonism) without affecting, to any significant degree the transmembrane influx of sodium through the fast channel. This results in a reduction of free calcium ions available within cells of the above tissues." "Verapamil is a potent smooth muscle relaxant with vasodilatory properties, as well as a depressant of myocardial contractility, and these effects are largely independent of autonomic influences. Its antianginal action in exertional angina seems to result from a decrease in resistance in the systemic vasculature, as well as from a direct effect on myocardial contraction. The net pharmacologic effect is a decrease in myocardial oxygen consumption. Verapamil's effectiveness in vasospastic angina is due to a decrease in coronary vascular tone."
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